Description

The antibody reacts with CD19, a Blymphocyte-lineage differentiation antigen. CD19, a 95-kDa transmembrance glycoprotein, is amember of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the matureB-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associateswith CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellularactivation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cellsin the bone marrow and periphery

Stability & Storage:

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Product Notices

1. This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μL experimental sample (a test).

2. Isotype control is not needed because the antibody has no Fc region.

For Research Use Only.

References

1. Schlossman SF, Boumsell L, Gilks W, et al, ed. Leukocyte Typing V: White Cell Differentiation Antigens. New York: Oxford University Press; 1995.

Knapp W, Dorken B, Rieber EP, et al, ed. Leucocyte Typing IV. New York: Oxford University Press; 1989.